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โ† Trials
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High Fructose Diet, the Gut Microbiome, and Metabolic Health

RecruitingNAAges 25 Years - 45 YearsAllIcahn School of Medicine at Mount Sinai
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In plain words

What the trial is, and whether it could suit you

Americans commonly consume excess amounts of dietary fructose. Added fructose has been shown to have an adverse impact on metabolic health, including increased insulin resistance and type 2 diabetes (T2D) risk. However, the mechanisms that link dietary fructose and metabolic health are poorly understood. Malabsorption or incomplete metabolism of fructose in the small intestine is common in the population. Excess fructose reaches the colon where it may change the structure and function of the gut microbiome, alter bacterial metabolites and trigger inflammatory responses impacting T2D risk. To elucidate whether commonly consumed levels of dietary fructose influence metabolic outcomes through altering the gut microbiome, the research team will randomize 30 participants to a controlled cross-over dietary intervention, in which the participants will consume 12-day isocaloric, added fructose o

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Participants must be determined to be a fructose malabsorber (screening visit) via hydrogen breath test. Exclusion Criteria: * Use of probiotic/prebiotic/synbiotic supplements * Consumption of \> 1 sugar sweetened beverage per day * Antibiotics within 3 months prior to enrollment or during intervention * Vegetarian, vegan or other restrictive dietary habits * Food allergy * Alcohol consumption in excess of 2 drink per day The following additional factors will be exclusion criteria: * Physician diagnosis of a major medical illness (including type 1 or type 2 diabetes) or eating disorder * Physical, mental, or cognitive handicaps that prevent participation * Chronic use of any medication that may affect body weight or composition, insulin resistance, or lipid profiles; * Current smoking (more than 1 cigarette in the past week) or use of other recreational drugs; e) restrictive dietary habits; * food allergy; * excess alcohol consumption; * recent use of pro-, pre- or Synbiotics of receipt of antibiotics within 3 months prior to enrollment or during the intervention; * consumption of greater than 1 sugar sweetened beverage per day prior to enrollment
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What it tests

  • Fructose
  • glucose
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Where

1 site
Mount Sinai Morningside
New York, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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