🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Mechanisms of Pulmonary Vascular Dysfunction in Heart Failure

Recruitingn/aAges 18 Years - anyAllInstitute for Clinical and Experimental Medicine
NCT06331208 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Heart failure (HF) patients often develop pulmonary hypertension (PH) that leads to transition into a biventricular HF with poor prognosis. There are two PH components: 1) passive transmission of increased left atrial pressure, 2) heart failure (HF) related pulmonary vascular dysfunction (PVD) with increased vascular resistance. Intriguingly, only some, but not all HF patients develop heart failure-related PVD. The mechanisms and non-invasive detection of HF-PVD are poorly understood and are the focus of the current grant application. Development of PVD is linked to insufficiently characterized metabolic factors that may be mediators of HF-PVD. Untargeted metabolomics is an emerging powerful platform for the discovery of pathways linked to diseases. Its specificity can be further enhanced using transpulmonary gradient sampling. Part A of the project aims to identify novel metabolites

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
A) Inclusion Criteria HF group: * age\>18y * signed informed consent, * left ventricular (LV) ejection fraction \<50% * duration of HF\>6 months, * loop diuretic use, * clinical indication to right heart catheterisation Control group: * Age \>18years * Signed informed consent * Non-HF subjects referred to Institute for Clinical and Experimental Medicine (IKEM) in Prague for an invasive procedure (PFO closure, arrhythmia ablation, for subjects undergoing RHC) or non-invasive diagnostic evaluation (controls without invasive sampling) B) Exclusion Criteria: Heart Failure group: * Patients with hemodynamic instability requiring inotropic support * Severe renal insufficiency (estimated glomerular filtration rate \<0.6 ml/s) * Acute coronary syndrome * High cardiac output (cardiac index \>4 l/m2) * Known pulmonary hypertension of other type than II (type I, III, IV) * Active infection * Respiration insufficiency * Large pleural effusion * Severe intrinsic lung disease (treated chronic obstructive pulmonary disease (COPD) * asthma, known interstitial lung disease) Control group: * Pulmonary hypertension (RV systolic pressure estimate on screening \> 45 mmHg) * History of recent pulmonary embolism \< 1 year * Echocardiographic evidence of reduced function of right or left ventricle * Treated asthma/COPD, known intersticial lung disease * Significant exercise intolerance (NYHA \> II)
💊

What it tests

  • non-contrast chest CT
  • spirometry with diffusing lung capacity for carbon monoxide (DLCO) analysis
  • Omics analysis of blood plasma obtained from pulmonary artery or peripheral blood
  • supine bike exercise during right heart catheterisation
  • Lung ventilation/perfusion SPECT
📍

Where

1 site
Institute for Clinical and Experimental Medicine - IKEM
Prague, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy