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โ† Trials
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Restoration of Immunity to Vaccine Preventable Diseases After CART-T Cell Therapy

Recruitingn/aAges 18 Years - anyAllInsel Gruppe AG, University Hospital Bern
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn about vaccine immunity in patients with B-cell malignancies treated by chimeric antigen receptor T-cell therapies (CAR-T). The main questions it aims to answer are: * Do CAR-T cell therapy recipients lose vaccine protection against common vaccine-preventable pathogens * Are current re-vaccination recommendations sufficient in restoring vaccine-protection * Is this restored vaccine-protection after CAR-T cell therapy lost faster than usual * Do clinical or immunological factors predict vaccine response after CAR-T cell therapy

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patient โ‰ฅ 18 years old * Suffering from a B-cell malignancy (B-cell acute lymphoblastic leukemia (ALL), B-cell non-hodgkin lymphoma (NHL), Follicular lymphoma (FL), Mantle Cell Lymphoma (MCL), Multiple myeloma (MM)) * Planned for a CAR-T cell therapy * Provided written informed consent Exclusion Criteria: * Previous or already started CAR-T cell therapy * \< 18 years old * Lack of consent
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What it tests

  • Vaccines against: Diphtheria, tetanus, pertussis, polio, haemophilus influenza type b, varicella and measles
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Where

1 site
University Hospital Bern
Bern, Switzerland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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