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Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain

RecruitingNAAges 18 Years - 60 YearsFemaleUniversity of Ottawa
NCT06333353 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this research is to improve pain outcomes for the over 500K Canadian women, girls and gender-diverse individuals who are newly diagnosed with endometriosis each year. Chronic pain that persists after interventions for endometriosis is a huge problem. There is some evidence that endometriosis-associated pain (EAP) is, at least to some extent, associated with changes in pain physiology, particularly central sensitization of pain. There is currently no effective evidence-informed intervention that addresses EAP. Yet a recent feasibility trial on a repetitive transcranial magnetic stimulation (rTMS) intervention demonstrated promising results compared to a sham intervention for reducing pain in a sample with EAP. The objectives of this trial are: 1. to evaluate the effectiveness of an rTMS intervention for pain reduction among those with recalcitrant post-operative EAP, 2. to i

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📋 Eligibility rules (as published)
Inclusion Criteria: -self-reported endometriosis-associated pain (\> 3 in the numeric rating scale, 0-10) that has persisted following medical or surgical intervention, Exclusion Criteria: * Contra-indications to rTMS (e.g., metal/implants around the head/neck, pacemaker), history of epilepsy (history of seizures) in the family * Pain symptoms initiated by other known causes (e.g., infections, thyroid disease, autoimmune diseases, gastrointestinal disease) * Experience a more severe, extra-pelvic pain than that associated with endometriosis * Pregnancy
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What it tests

  • Real RepetitiveTranscranial Magnetic Stimulation 5 sessions
  • Sham RepetitiveTranscranial Magnetic Stimulation 5 sessions
  • Real RepetitiveTranscranial Magnetic Stimulation 10 sessions
  • Sham RepetitiveTranscranial Magnetic Stimulation 10 sessions
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Where

1 site
McLean Function Measurement Lab
Ottawa, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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