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Total Underwater Colonoscopy (TUC) for Improved Colorectal Cancer Screening: A Randomized Controlled Trial

RecruitingNAAges 55 Years - 60 YearsAllVestre Viken Hospital Trust
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In plain words

What the trial is, and whether it could suit you

Colorectal cancer (CRC), the third most diagnosed cancer and second most common cause of cancer death. CRCs develop from precursors like adenomas (about 70% of CRCs) or serrated lesions (SSLs) (about 25-30% of CRCs). Colonoscopy is the cornerstone in CRC screening, in screening programmes often as a work-up examination after a positive primary screening test such as faecal immunochemical test (FIT). Norway and Sweden have recently launched a nationwide faecal haemoglobin CRC screening programmes. Recently, both a Dutch and an Austrian study showed that SSL detection rate (SSLDR) is inversely correlated to CRC at follow-up. Consequently, improved SSLDR can reduce the risk of post-colonoscopy CRC. SSLs are typically located in the right colon. They are flat, with indistinctive boarders, and consequently easily missed or incompletely resected. A Norwegian study showed incomplete resection o

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * All individuals referred to colonoscopy after a positive FIT screening at the participating screening centres Exclusion Criteria: * Individuals with a CRC diagnosis within the last 10 years.
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What it tests

  • Total underwater colonoscopy
  • Conventional colonoscopy
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Where

5 sites
Vestre Viken Health Trust, Bærum Hospital
Drammen, Norway
Østfold Hospital Health Trust
Grålum, Norway
Akershus University Hospital Health Trust
Lørenskog, Norway
Ullevål University Hospital Health Trust
Oslo, Norway
Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden, Department of Medicine, Geriatrics and Emergency Care Mölndal
Gothenburg, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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