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Observational Study of the Structural-functional Connectome in Patients With Epilepsy

Recruitingn/aAges 6 Years - 65 YearsAllIRCCS Eugenio Medea
NCT06334029 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Over the past decade, the concept of the brain as a complex network has extremely influenced the way regarding how the latter is studied (Bartolomei et al., 2017). The structure of both structural and functional networks within the brain has been related to optimal brain functioning (Duma et al., 2022). This evolution of methods and approaches of investigation has directly impacted the study of epilepsy. An early conception of focal epilepsy was that it was related to the activity of the epileptogenic zone, which was identified as the generative element of seizures. However, what was previously considered focal was found to be network alterations at various levels, thus moving from the epileptogenic zone to the concept of the epileptogenic network. Alterations in both the structural and functional network, compared with a healthy control population, have been identified in various forms

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📋 Eligibility rules (as published)
Inclusion Criteria: * a diagnosis of focal or generalized epilepsy confirmed by specialist evaluation; * at least one MRI scan of the brain that includes T1w * at least one recording with resting state EEG * age between 6 and 65 years at the time of the evaluation of the present study; * ability to take part in a neuropsychological assessment. Exclusion Criteria: * vascular causes or non-low grade tumors as causes of epilepsy * age different from the range 6-65 years * neuroradiologic examination not complete * absence of resting state recording * inability to take part in a neuropsychological evaluation.
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What it tests

  • Functional and structural Connectome
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Where

1 site
IRCCS E.Medea
Conegliano, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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