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Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps

RecruitingNAAges 18 Years - anyAllOdense University Hospital
NCT06335420 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel. The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans? Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar. Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Any type of resection for adenomas larger than 20 mm in size (endoscopically evaluated) or endoscopically resected T1 cancers. 2. Acceptance of the treatment and follow-up program. 3. Capability to understand and follow the instructions. Exclusion Criteria: 1. Patients allocated to "high-risk" group because of many small polyps (\>4). 2. Pregnancy. 3. Known relevant allergies. 4. Chronic consumption of COX (cyclooxygenase) inhibitors (Aspirin, Celecoxib, Ibuprofen, Diclofenac, Ketoprofen, Ketorolac, Indometacin, Naproxen, Piroxicam) or immunosuppressive agents (Methotrexate, Azathioprine or glucocorticoids). 5. Patients with different neoplastic disease under treatment (Chemo-/Radio-/Imunotherapy). 6. Severe comorbidity NYHA III-IV. 7. Lynch syndrome.
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What it tests

  • Carrot juice from Yellowstone carrots cultivars
  • Placebo juice
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Where

1 site
Department of Surgery, Odense University Hospital
Odense, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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