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Mental Imagery and Targeted Memory Reactivation in Insomnia

RecruitingNAAges 18 Years - 45 YearsAllUniversity Hospital, Geneva
NCT06335784 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this clinical trial, the investigators test whether mental Imagery Rescripting (IR), a technique where the individual is instructed to transform a negative memory or image into a positive one, and olfactory Targeted Memory Reactivation (TMR), a technique used to strengthen memories, can reduce hyperarousal and insomnia severity in patients with Insomnia Disorder (ID). Patients with ID will be randomized into four groups: in the first group (SH group), patients will have 4 weekly sessions (1 session/week) of a minimal intervention for insomnia (sleep hygiene information) in the presence of an odorless diffuser, which will be also used during the night. In the second group (IR group), patients will use IR during wakefulness to induce a state of relaxation and positive emotionality. More specifically, during 4 weekly sessions of IR, patients will imagine a negative scenario related to t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 45 years * Insomnia disorder according to the International Classification of Diseases 3 (ICSD-3) * ISI \> 10 * PSQI \> 5 * No other current treatment for Insomnia Exclusion Criteria: * patients with another psychiatric disorder requiring acute treatment according to DSM-5 * patients with medical (e.g. neurological disorders) or other disorders explaining the predominant complaint of insomnia (e.g., sleep apneas with ODI\>15/h, restless legs syndrome, periodic limb movements with PLM\>15, chronic pain) * patients with significant substance use/withdrawal * patients with heavy smoking * known pregnancy * patients suffering from anosmia, olfactory related issues and respiratory pathology
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What it tests

  • Imagery Rescripting (IR)
  • Imagery Rescripting (IR) and Targeted Memory Reactivation (TMR) during sleep
  • Sleep Hygiene
  • Sleep Hygiene + Odor
  • "Rocking bed" if patients still have insomnia complaints (ISI >10) after the 4 weeks of the intervention
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Where

1 site
Center for Sleep Medicine
Geneva, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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