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Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Study

Recruitingn/aAges 18 Years - 80 YearsAllAnhui Medical University
NCT06336174 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to explore the mechanism of cognitive impairment in patients with symptomatic intracranial atherosclerotic stenosis (ICAS), and further plans to explore the impact of different treatment options on cognitive function in symptomatic ICAS patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 80 years * Severe stenosis (≥70%-99%) of atherosclerotic internal carotid artery (C6 segment, C7 segment) or middle cerebral artery (M1 segment) confirmed by digital subtraction angiography (DSA) or at least two of the following non-invasive examinations: magnetic resonance angiography (MRA), computed tomography angiography (CTA), or transcranial Doppler (TCD) * Transient ischemic attack (TIA) or minor stroke (National Institute of Health Stroke Scale \[NIHSS\] score ≤ 4 points) * Right-handed and able to cooperate in neuropsychological tests * At least 14 days post-onset of cerebral infarction or TIA * Signed informed consent Exclusion Criteria: * Other diseases that affect cognitive function, such as cerebral hemorrhage, •Parkinson's disease, neurosyphilis, dementia, tumors, etc. * Right upper limb hemiplegia, aphasia, visual field defects, or visual impairments * More than 50% stenosis of the extracranial internal carotid artery, the vertebral artery, or the basilar artery * Vasculitis, moyamoya disease, and cardiogenic stroke * Previous history of head and neck stent implantation, carotid endarterectomy, aneurysm embolization, or other intracranial surgeries
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What it tests

  • Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
  • Endovascular therapy,Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
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Where

1 site
Anhui Medical University
Hefei, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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