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Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis

Recruitingn/aAges 18 Years - anyAllIRCCS SYNLAB SDN
NCT06337227 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex; * Patients without atherosclerosis undergoing surgical procedure for endocarditis; * Patients who will have signed informed consent Exclusion Criteria: * Patients for whom biological material cannot be recovered for study purposes; * Patients who refuse to participate in the study
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What it tests

  • lncRNA signature analyses
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Where

1 site
Irccs Synlab Sdn
Naples, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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