Personalized Anticoagulant Therapy for Pulmonary Thromboembolism

Inclusion Criteria: 1. Age ≥ 18 years old; 2. Adult patients with objectively diagnosed pulmonary thromboembolism (PTE) (with or without concomitant deep vein thrombosis); 3. Specific populations meeting any of the following criteria: elderly patients (≥75 years old); patients with impaired kidney function (creatinine clearance estimated by the Cockcroft-Gault formula, CrCl \< 60ml/min); patients with active malignancies (under treatment or with unrecovered malignancies); 4. Patients who have not started anticoagulant therapy before enrollment and are planned for anticoagulant treatment after evaluation by the attending physician; 5. Ecpected life expectancy longer than 3 months. 6. Patients who understand and agree to participate in this study, sign the informed consent form, and adhere to regular follow-up visits. Exclusion Criteria: 1. Moderate or severe liver dysfunction (Child-Pugh class B or C); 2. Spontaneous bleeding tendency, such as coagulation disorders or thrombocytopenia (PLT\<20×10\^9/L); 3. Contraindications to anticoagulant drugs, including allergy to anticoagulants, clinically significant active bleeding, significant risk of major bleeding due to lesions or conditions, significantly abnormal coagulation function, liver disease with clinically relevant bleeding risk, thrombocytopenia, etc., as determined by the attending physician; 4. High-risk pulmonary embolism requiring thrombolysis; 5. Patients currently participating in other clinical trials.