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Study of the Steroid Hormone Milieu in Obese Patients

Recruitingn/aAges 18 Years - 80 YearsMaleIstituto Auxologico Italiano
NCT06341699 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this observational study is to evaluate the actual secretion of cortisol and testosterone in obese male subjects, together with the receptor sensitivity to these hormones in order to understand whether the hormonal milieu deriving from these parameters is associated with alterations in bone metabolism, lipoprotein concentration and function, and/or the severity and complications of obesity. It will be also investigated if this hormonal milieu is a predictive factor for cardiovascular disease in obese patients. Eligible subjects are male patients (age 18-80 years) with severe obesity and no other known causes of hypercortisolism or hypogonadism. Questionnaires for the evaluation of mood and symptoms will be collected upon enrollment, patient's anamnestic and clinical data relating to disease complications, BMI, previous blood tests, cortisol suppression with dexamethasone 1

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📋 Eligibility rules (as published)
Inclusion Criteria: * morbid obesity Exclusion Criteria: * patients suffering from severe systemic pathologies, fever, chronic inflammatory states known to cause PCR \>10 mg/dL * use of corticosteroids at the time of enrollment * the patient's poor understanding of spoken and written Italian * patients suffering from primary pathologies of the testicle, known at enrollment * patients suffering from hypothalamic-pituitary or adrenal pathologies already known at the time of enrollment
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What it tests

  • Not listed
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Where

1 site
Istituto Auxlogico Italiano, Hospital San Giuseppe, Piancavallo
Oggebbio, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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