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Early Onset Colorectal Cancer Detection

Recruitingn/aAges 18 Years - 50 YearsAllCity of Hope Medical Center
NCT06342401 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women. This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Stage I, II, III, IV colorectal cancer (TNM classification, 8th edition) diagnosed before the age of 50 (EOCRC cases) * Received standard diagnostic and staging procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment * Colonoscopy-proven cancer-free status at the time of study inclusion (Non-disease controls) Exclusion Criteria: * Hereditary colorectal cancer syndromes (identified through genetic testing) * Inflammatory bowel diseases * Lack of written informed consent
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What it tests

  • ENCODE
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Where

13 sites
City of Hope Medical Center
Duarte, United States
IRCCS San Raffaele
Milan, Italy
Kawasaki University
Kawasaki, Japan
Mie University
Mie, Japan
National Cancer Center Hospital
Tokyo, Japan
Tokyo Medical and Dental University
Tokyo, Japan
Yamagata University
Yamagata, Japan
Barcelona University
Barcelona, Spain

…and 5 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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