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Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

RecruitingPhase 1Ages 18 Years - anyAllTheRas, Inc., d/b/a BBOT (BridgeBio Oncology Ther…
NCT06343402 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A first in human study to evaluate the safety and preliminary antitumor activity of BBO-8520, a KRAS G12C (ON and OFF) inhibitor, as a single agent and in combination with pembrolizumab and BBO-10203 in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS (Kirsten rat sarcoma) G12C mutation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically documented locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS G12C mutation * Measurable disease by RECIST v1.1 * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1 Exclusion Criteria: * Patients with malignancy within the last 2 years as specified in the protocol * Patients with untreated or unstable brain metastases * Patients with known hypersensitivity to BBO-8520 or its excipients * For Cohorts 1b and 2b: * Patients with a known hypersensitivity to pembrolizumab or its excipients * Patients with active autoimmune disease of history of autoimmune disease that might recur * Patients with a history of interstitial lung disease/pneumonitis that required steroids, or current interstitial lung disease/pneumonitis Other inclusion/exclusion criteria may apply
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What it tests

  • BBO-8520
  • Pembrolizumab
  • BBO-10203
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Where

38 sites
O'Neal Comprehensive Cancer Center at UAB
Birmingham, United States
University of California - San Diego Moores Cancer Center
La Jolla, United States
University of California San Francisco
San Francisco, United States
UCLA Health - Santa Monica Cancer Care
Santa Monica, United States
University of Colorado Cancer Center
Aurora, United States
Yale Cancer Center
New Haven, United States
Norwalk Hospital
Norwalk, United States
OSF Saint Francis Medical Center
Peoria, United States

…and 30 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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