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Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia

Recruitingn/aAges 18 Years - anyAllCiusss de L'Est de l'Île de Montréal
NCT06346158 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to explore the variability of the concentration at the effect site (Ce) of propofol to reach deep anesthesia (DA) during induction of general anesthesia in adults. The investigators hypothesized that there is a great variability in this Ce that could be precisely explained by * Electroencephalographic (EEG) features available prior to induction of anesthesia * Cognitive performance * Patients characteristics Participants will undergo preoperative cognitive testing and awake EEG. Then, induction of general anesthesia will be performed using continuous infusion of propofol. The Ce at which Deep anesthesia is observed will be recorded.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Scheduled for any kind of surgery under general anesthesia. * Adults Exclusion Criteria: * Inability to communicate in French or English, * Known allergy or intolerance or other medical condition that precludes the use of prescribed general anesthesia protocol for this study, * Patients requiring rapid sequence induction, * Anticipated or known difficult intubation patient, * Anticipated or known difficult ventilation patient, * Body mass index ≥ 35 kg.m-2.
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What it tests

  • Cognitive testing
  • electroencephalogram
  • High density electroencephalogram
  • General anesthesia
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Where

1 site
Hopital Maisonneuve-Rosemont
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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