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Outcome of Pulp Revascularization of Necrotic Mature Permanent Teeth Using Platelet-rich Fibrin

RecruitingNAAges 12 Years - 60 YearsAllKing Abdullah University Hospital
NCT06347640 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Regenerative endodontic procedures are intended to replace damaged tooth structures, including dentine and root structures, in addition to cells of the pulp-dentine complex. This treatment modality have been tested on immature necrotic teeth because they are anticipated to have a greater chance of pulp tissue regeneration. However, it has been recently suggested for treating fully formed mature necrotic permanent teeth with closed apices since the conventional root canal treatment yielded many drawbacks. A number of studies have evaluated the regeneration outcomes of using blood clot as a scaffold. However, there are limited studies in the literature on using other scaffolds such as platelet-rich fibrin (PRF). This clinical study will evaluate clinically and radiographically the effectiveness of PRF versus induced bleeding in treating mature necrotic teeth. Fifty patients with necroti

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📋 Eligibility rules (as published)
Inclusion Criteria 1. Anterior or posterior mature tooth diagnosed with necrotic pulp in the presence of a periapical lesion, 2. Pulp space is not needed for post and core restoration. 3. Patients are not allergic to the medicaments necessary to complete the procedure. Exclusion Criteria 1. Medically compromised patient. 2. Patient with generalized chronic periodontitis. 3. Teeth with previous root canal treatment. 4. Periodontal pocket larger than 3mm. 5. Teeth with vertical fractures 6. Non-restorable teeth
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What it tests

  • induced bleeding
  • plasma rich fibrin
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Where

1 site
Jordan University of Science and Technology
Irbid, Jordan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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