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Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial

RecruitingNAAges 18 Years - anyAllThe George Institute
NCT06352619 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Several clinical trials have produced variable conclusions regarding the effects of intensive blood pressure (BP) lowering in post-EVT acute ischaemic stroke (AIS) patients. Although two trials indicate harm from very intensive target-based treatment (SBP \<130 mmHg), the others neutral effects in the SBP range 140-160 mmHg. The ENCHANTED3/MT domain of the ACT-GLOBAL platform trial aims to test different approaches to the treatment of elevated SBP in post-EVT AIS patients to find an optimal BP management strategy. ENCHANTED3/MT will randomize (1:1:1) up to 2,000 patients with SBP ≥150 mmHg post-EVT to conservative (no or minimal SBP reduction by 5-10mmHg or a target of 175-180mmHg if very-high baseline SBP \[≥180mmHg\]), moderate (SBP reduction by 10-20mmHg or a target of 160 ± 5, whichever is higher; no control if low-high baseline SBP \[150-160mmHg\]), or intensive (SBP reduction by 30

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥18 years; 2. Use of endovascular therapy (EVT) within 24 hours of symptom onset or last known well according to local guidelines; 3. Sustained high systolic blood pressure ≥150 mmHg (2 readings \<10 mins apart) within 3 hours after completion of EVT. Exclusion Criteria: 1.Any definite contraindications to BP lowering treatment.
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What it tests

  • Conservative SBP Control
  • Moderate SBP Control
  • Intensive SBP Control
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Where

2 sites
The George Institute for Global Health
Sydney, Australia
University of Calgary
Calgary, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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