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ACT-GLOBAL Adaptive Platform Trial for Stroke

RecruitingPhase 3Ages 18 Years - anyAllThe George Institute
NCT06352632 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Stroke is causing 6.6 million deaths and is a major cause of disability worldwide in 2019. There remains an urgent need for interventions that improve outcomes which can be implemented with wide applicability for stroke. ACT-GLOBAL is a multi-factorial, multi-arm, multi-stage, randomised, global adaptive platform trial for stroke, aiming to identify the treatment/s associated with the highest chance of improving outcome in stroke patients. In ACT-GLOBAL multiple questions will be evaluated simultaneously and sequentially as data accrues and can evaluate interactions between different treatment options.

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📋 Eligibility rules (as published)
Platform Inclusion Criteria: 1. Age ≥18 years 2. Clinical diagnosis of stroke Platform Exclusion Criteria: There are no platform level exclusion criteria Each state and domain will specify additional inclusion and exclusion criteria in the respective Domain-Specific Registration. Patients who fulfill the overall platform criteria will be assessed for enrollment into each active domain.
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What it tests

  • Standard-dose intravenous tenecteplase
  • Low-dose intravenous tenecteplase
  • No intravenous tenecteplase
  • Conservative Blood Pressure Control
  • Moderate Blood Pressure Control
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Where

2 sites
The George Institute for Global Health
Sydney, Australia
University of Calgary
Calgary, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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