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Efficacy of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.

RecruitingPhase 2Ages 18 Years - 80 YearsAllMansoura University
NCT06354712 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A prospective, randomized, controlled, parallel clinical trial will be conducted at Clinical Oncology and Nuclear Medicine Center at Mansoura University Hospital to assess the efficacy of N-acetylcysteine in the prevention of radiotherapy induced oral mucositis in Head and Neck cancer patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adults \>18 years diagnosed with squamous cell carcinoma of the head and neck scheduled to receive curative radiotherapy (Primary or postoperative) of at least 50 Gy with or without concurrent chemotherapy. 2. Individuals with healthy mucosa. 3. Adequate bone marrow function (Hemoglobin level ≥10 g/dL, platelet count ≥75 × 103/microliter, and absolute neutrophil count ≥1.5 × 103/microliter). 4. Patients with ECOG performance ≤2 Exclusion Criteria: 1. History of chemotherapy or radiotherapy. 2. Signs of systemic infections. 3. Pregnant and lactating women. 4. Individuals receiving systemic analgesics. 5. Liver disorders and renal failure with eGFR \<30 ml/min/1.73m2 (by the MDRD equation). 6. Inability to follow instructions and complete the questionnaires.
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What it tests

  • N-Acetyl-Cysteine with Institutional standard care
  • Institutional standard care
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Where

1 site
Clinical Oncology and Nuclear Medicine of Mansoura University Hospital
Al Mansurah, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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