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Driving Pressure-guided Lung Protective Ventilation

RecruitingNAAges 14 Years - 70 YearsAllYong Lin, PhD
NCT06361420 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving pressure-guided lung protective ventilation can reduce postoperative oxygenation function in patients who have undergone surgical repair of acute type A aortic dissection. The primary outcomes is the incidence of postoperative hypoxemia (a partial pressure of arterial oxygen to inspiratory oxygen fraction ratio less than 300 mm Hg or a peripheral blood oxygen saturation less than 93% at any concentration of inspiratory oxygen) within 7 days after the surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Able to sign Informed Consent and Release of Medical Information Forms; 2. Age ≥ 14 years and ≤ 70 years old; 3. Being confirmed the diagnosis by chest computed tomography angiography and receiving the surgical repair of acute type A aortic dissection. Exclusion Criteria: 1. Age \< 14 years or \> 70 years old; 2. Sepsis before surgery; 3. Chronic pulmonary disease including lung infection or asthma requiring long-term pharmacotherapy; 4. History of lung tumor; 5. Obstructive sleep apnea hypopnea syndrome requiring long-term noninvasive mechanical ventilation support; 6. Heart failure requiring catecholamines or invasive mechanical ventilation support; 7. Body mass index \> 30 Kg·m-2; 8. Being reluctance to participate this study.
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What it tests

  • Driving pressure-guided positive end expiratory pressure
  • Optimal oxygenation-guided positive end expiratory pressure
  • Ventilation strategy
  • Management of hypoxemia
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Where

1 site
Fujian medical university union hospital
Fuzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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