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Fatigue and Cognitive Dysfunction After Allogeneic Stemcell Transplantation, Prospective PET Study

Recruitingn/aAges 20 Years - 75 YearsAllKarolinska Institutet
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In plain words

What the trial is, and whether it could suit you

This study is the academic study and continuation and further development of a prior project under the leadership of Professor LeBlanc. Patients undergoing allogenic stem cell transplantation are followed up in the outpatient clinic. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Previous study by Boberg et al suggested distinct mRNA and proteomic profiles segregating fatigued from non-fatigued patients as well as patients with or without cognitive impairment. A larger well-defined patient cohort is necessary to confirm these results. Investigators aim to identify specific sets of proteins in the CSF that can serve as potential biomarkers of cognitive dysfunction and/or fatigue. This will be performed with two methods: * by using mass spectrometry-based proteomics approaches * Olink tec

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * status 1-5 years after HSCT * no known CNS disorders or psychiatric disturbances Exclusion Criteria: * prior TBI or CNS irradiation / intrathecal therapy * known neurological or psychiatric disorder * time less then 1 year or over 5 years after transplantation
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What it tests

  • Not listed
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Where

1 site
Karolinska
Stockholm, Sweden
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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