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Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression

RecruitingNAAges 18 Years - 65 YearsAllJakub Antczak
NCT06363981 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat. rTMS is a relatively novel treatment option, whose therapeutic potential is still investigated and optimized. The aim of this study is to assess the effect of rTMS applied over two stimulation sites on cognitive impairment, anhedonia and sleep disorders in depression.

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📋 Eligibility rules (as published)
Inclusion Criteria: * severe or moderate depressive episode (according to international classification of diseases (ICD)-10) without psychotic symptoms at the time of inclusion * Hamilton Depression Rating Scale between between 20 and 35 points at inclusion * The score in the Athens Insomnia Scale eight or more * The score of three or more points in items 4 and 21 of the Beck Depressions Inventory 2 * Complaining about problems with memory and concentration timely related with the onset of depression Exclusion Criteria: * Contraindications to transcranial magnetic stimulation, including ferromagnetic elements in head, pregnancy and epilepsy * Psychotic symptoms at the time of inclusion * Suicidal ideations and/or attempts within three months prior to inclusion
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What it tests

  • Active rTMS over the left DLPFC and over the left DMPFC
  • Active rTMS over the left DLPFC
  • Sham rTMS
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Where

1 site
The Education of Research and Development Center, Babinski Clinical Hospital
Krakow, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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