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Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Recruitingn/aAges 40 Years - anyAllTufts Medical Center
NCT06365060 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients 40 years of age and older * diagnosed with either Smoldering Multiple Myeloma or a Monoclonal Gammopathy * dFLC greater than 23 mg/L * abnormal FLC ratio * If the patient has an eGFR less than 50 mL/min/1.73m2, the FLC ratio is inconsequential. The patient only needs to meet the age and dFLC criterion. Exclusion Criteria: * Patients younger than 40 years of age are not eligible * Patients with a previous finding of amyloid in other biopsies will not be included * Adults unable to consent are not eligible, including the cognitively impaired Pregnant women, pregnant minors, minors (i.e., individuals who are not yet adults), wards of the state, non-viable neonates, neonates of uncertain viability, and prisoners are not eligible
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What it tests

  • Not listed
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Where

13 sites
University of Alabama Hospital
Birmingham, United States
Cedars-Sinai Medical Center
Los Angeles, United States
University of California, San Francisco
San Francisco, United States
Cleveland Clinic Florida, Weston Hospital
Weston, United States
Tufts Medical Center
Boston, United States
Columbia University Irving Medical Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Atrium Health Levine Cancer Institute
Charlotte, United States

…and 5 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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