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Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique

Recruitingn/aAges 18 Years - anyAllUniversity Hospital Center of Martinique
NCT06365359 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chlordecone, an organochlorine pesticide, was widely used on banana farms in the French West Indies. Studies by Inserm and health authorities have confirmed the contamination of the food chain and the majority of the population of the French West Indies by chlordecone. Epidemiological studies conducted in the French West Indies have shown that exposure to chlordecone at the levels observed is associated with an increased risk of developing several diseases, including premature birth and prostate cancer. Many of the adverse effects associated with chlordecone could be explained by its estrogenic hormonal properties, and systemic lupus erythematosus (SLE) is an autoimmune disease whose sensitivity to estrogen is well known and is reflected by 1) its clear predominance in women, 2) its predominance in women of childbearing age, 3) its risk of exacerbation in the event of pregnancy. Chlord

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with systemic lupus erythematosus according to the ACR 1997 or ACR/EULAR 2019 criteria, * Present in the active line of the internal medicine department of the Martinique University Hospital since 2005, * Whose illness has been progressing for at least 3 years, * Living in Martinique or Guadeloupe for at least 1 year, * Patients who have given their free, informed and written consent. Exclusion Criteria: * Patients for whom kidney disease cannot be authenticated or ruled out (refusal, contraindication or impossibility of renal biopsy), * Patients without social security coverage, * Current legal protection, * Patients who have not given their consent to the use of their data, * Pregnant or breastfeeding women.
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What it tests

  • Blood sample for analysis of plasma of organochlorine pesticides concentration
  • Blood sample for cell collection
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Where

1 site
University Hospital Center of Martinique
Fort-de-France, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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