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Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS

RecruitingNAAges 18 Years - 70 YearsAllTongji Hospital
NCT06367218 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery. The "opioid-sparing strategy," which substitutes ketamine for opioids during surgery, not only provides effective analgesia but also protects perioperative lung function and reasonably prevents the occurrence of opioid-related adverse reactions; it also reduces medical costs and shortens the average hospital stay. However, the degree of benefit to patients lacks high-level clinical evidence. This study aims to comprehensively assess the effect of opioid-free combined anesthesia with preserved spontaneous breathing for VATS lung nodule surgery on postoperative rapid recovery from multiple aspects including postoperative lung function and pulmonary complications, pain, gastrointestinal function, nause

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. ASA grades 1-2 2. Age \> 18 years and \< 70 years 3. Male or female patients 4. VATS pulmonary nodule operation is planned under general anesthesia 5. Voluntarily participate in the study and sign the informed consent Exclusion Criteria: 1. Subject's operation is aborted 2. Serious adverse events, complications or special physiological changes during the perioperative period should not be continued 3. Expansion of surgical scope: resection of complex lung segment or complex lung lobectomy, thoracoscopic assisted small-incision surgery with enlarged incision, requiring pulmonary blood Tracheoplasty or bronchoplasty, partial pericardiectomy or conversion to thoracotomy 4. Those who need a second operation within a month 5. The patient or his/her guardian requests to withdraw on his/her own 6. Reasons why other researchers think the study needs to be discontinued
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What it tests

  • opioid based strategy
  • opioid-free strategy
  • Laryngeal mask airway; Preserved spontaneous breathing
  • Double lumen tracheal tube; Mechanical ventilation
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Where

1 site
Tongji Hospital
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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