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Effects of Protein and NAC Co-ingestion on Skeletal Muscle Recovery

RecruitingNAAges 18 Years - 27 YearsMaleUniversity of Thessaly
NCT06367413 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Previous evidence suggests that though N-acetylcysteine (NAC) supplementation following eccentric exercise-induced muscle damage disrupts the skeletal muscle's repair and remodelling process at 8 days of recovery, it attenuates substantially the decline of skeletal muscle performance during the first 48 hours of recovery. The enhanced performance capacity during the first phase of recovery in response to NAC supplementation might be attributed to the altered redox status in skeletal muscle as a consequence of the NAC-mediated elevation of reduced glutathione (GSH) levels. The rise in GSH results in a redox-dependent attenuation of immune cell mobilisation and reduction of oxidative stress response, leading to a blunted rise of muscle damage and inflammatory markers during the first 2-3 days of recovery. However, following exercise-induced muscle damage, protein synthesis increases in ske

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📋 Eligibility rules (as published)
Inclusion Criteria: * Free of asthma, kidney disease, bleeding disorders, peptic ulcers. * Free of musculoskeletal injuries and limitations. * Abstain from dietary energy restriction. * Do not use medication such as anti-inflammatory drugs, antibiotics, antihypertensive drugs or anticoagulants. * Do not use dietary supplements such as protein, carbohydrate, antioxidants, vitamins etc. * Free of N-acetylcysteine intolerance. * Non-smokers. * Abstain from alcohol throughout the study. Exclusion Criteria: * Presence of asthma, kidney disease, bleeding disorders, peptic ulcers. * Musculoskeletal injuries and limitations. * Dietary energy restriction. * Use of anti-inflammatory drugs, antibiotics, antihypertensive drugs or anticoagulants. * Use of dietary supplements such as protein, carbohydrate, antioxidants, vitamins etc. * N-acetylcysteine intolerance. * Smoking. * Alcohol consumption during the study.
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What it tests

  • Placebo
  • NAC
  • NAC + Whey Protein
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Where

1 site
Department of Physical Education and Sport Science, University of Thessaly
Trikala, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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