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Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.

Recruitingn/aAges any - anyAllXinhua Hospital, Shanghai Jiao Tong University Sc…
NCT06367946 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age. 2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Lung tissues from patients with different ages: Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3; 2. Peripheral blood from patients with different ages and duration of mechanical ventilation: Patients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3; Exclusion Criteria: 1. Lung tissues from patients with different ages: Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women. 2. Peripheral blood from patients with different ages and duration of mechanical ventilation: Patients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension/diabetes/coronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
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What it tests

  • mechanical ventilation
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Where

1 site
Shanghai Xinhua hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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