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ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study

RecruitingEARLY Phase 1Ages 18 Years - 60 YearsAllUniversity Hospital, Basel, Switzerland
NCT06370845 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.

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📋 Eligibility rules (as published)
Inclusion Criteria Obese Participants: * Age 18-60 years * Written informed consent * Scheduled for routine liquor puncture * BMI ≥ 30 kg/m2 * No proven diagnose of diabetes Inclusion Criteria Lean Participants: * Age 18-60 years * Written informed consent * Scheduled for routine liquor puncture * BMI 18-25 kg/m2 Exclusion Criteria: * Known allergy to the natural odour * Acute upper respiratory tract infection, acute or chronic sinusitis * Present or past surgical intervention of the nasal cavity, the paranasal sinus, the pituitary or the frontal brain * Pregnancy/lactation * Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease, severe renal impairment with an estimated glomerular filtration rate \<30 ml/min/m2) * Inability to understand the study procedure and to sign the study consent
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What it tests

  • Inhalation - Natural Odour
  • Inhalation - Placebo
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Where

2 sites
University Hospital Basel
Basel, Switzerland
University Hospital of Basel
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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