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Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome

RecruitingNAAges 18 Years - 65 YearsAllThe Hong Kong Polytechnic University
NCT06376500 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases. It is estimated that 40-80% of individuals with mTBI may experience the post-concussion syndrome (PCS), which is characterized by a range of physical, cognitive, and emotional symptoms. Although the underlying basis of cognitive dysfunction of patients with persistent PCS remains to be clarified, converging evidence shows that the clinical symptoms is underpinned by abnormal neural information processing as a result of axonal injury due to mTBI. Recent studies have demonstrated abnormalities in both structural and functional cortical connectivity, and a loss of cortical excitability-inhibitory (E/I) balance after TBI. Yet, there is no consensus for treating chronic symptoms of concussion, and PCS remains a chronic and highly d

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📋 Eligibility rules (as published)
Inclusion Criteria: * being 18 years old or older; * having a history of a mild TBI (less than 30 minutes loss of consciousness) 1-6 years prior to the study; * able to communicate in Chinese. Exclusion Criteria: * being without a confirmed diagnosis from the medical practitioner; * having a history of other neurological and psychiatric disorders, skull defect, recent medical instability (within 3 weeks); * being pregnant; * being medication for a psychiatric condition (e.g., major depression, anxiety, schizophrenia); * with any implanted devices or suffering from real claustrophobia or feel uncomfortable in small, enclosed spaces, like MRI tunnel
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What it tests

  • tDCS with cognitive training programme
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Where

1 site
The Hong Kong Polytechnic University
Hung Hom, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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