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Multi-organ Responses to CHronic Physical Activity and INactivity

RecruitingNAAges 50 Years - 65 YearsAllUniversity of Nottingham
NCT06377254 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual. Persistent physical inactivity is thought to be a key contributing factor to the risk of poor health and functional decline occurring in middle-aged and older adults. It is therefore concerning that most middle-aged adults spend \>8hrs/day being sedentary, with average step count of 3000-4000 steps/day. To be able to holistically assess the effectiveness of future strategies to address age-related decline in health, and devise public health messages to help individuals reach older age in better health, it is essential that the complex physiological effects that activity and inactivity have across biological systems are characteri

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📋 Eligibility rules (as published)
Inclusion Criteria: * Group 1 ('non-sedentary') self-reporting \<6 sedentary hrs/day, not actively involved in exercise training or a regular physical activity regimen (\>8,000 steps/day). * Group 2 ('sedentary') self-reporting ≥8 waking hrs/day in sedentary activities and/or ≤5,000 steps/day. * Aged 50-65y. * Overweight (BMI 25-35 kg/m2). * Waist circumference ≥94cm (males) and ≥80cm (females). * Willing to alter physical activity levels as instructed for 6 months * Without neurological or psychiatric diseases, motor or cognitive restrictions * Ability to give informed consent Exclusion Criteria: * Regular medication use that could interfere with measures * A history, or evidence, of chronic cardiovascular, metabolic, musculoskeletal, renal or respiratory diseases. * Experiencing 'long-COVID', inflammatory bowel disease or malignancy. * Uncontrolled hypertension. Stage 1 hypertension (BP ≤160/100mmHg) with no other signs of cardiovascular disease, and blood pressure (BP) managed by routine medication will not be an exclusion. * People employed in jobs that would preclude reducing step count and night-shift workers. * Females who are pre/peri-menopausal, (due to effect of oestrogen fluctuations on primary outcomes and the longitudinal study design), but individuals stable on hormone replacement therapy are eligible. * Contraindications for MRI. * Allergy or sensitivity to local anaesthesia, or dressing adhesive
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What it tests

  • Decreased Physical Activity
  • Increased Physical activity
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Where

1 site
David Greenfield Human Physiology Unit
Nottingham, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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