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Effect of Propofol vs. Sevoflurane on Erections During Narcosis In Transurethral Surgery

RecruitingPhase 4Ages 18 Years - 75 YearsMaleEtienne Xavier Keller
NCT06378645 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Penile erection is an unwanted event in transurethral (through the urethra) surgeries, which may be associated with adverse outcomes such as impaired access, prolonged operation time, the need to abort the operation, or the necessity for ancillary measures to achieve penile flaccidity, such as the injection of certain medications directly into the penis. To reduce greenhouse gas emissions, the primary use of propofol instead of gaseous agents is being recommended for general anesthesia. Whether propofol may be associated with an increased or decreased rate of unwanted intraoperative penile erection compared to other anesthetic agents is not known. More generally, there are no high-quality studies available to evaluate the impact of the type of general anesthesia on the risk of unwanted penile erections during surgery. This study aims to determine whether general anesthesia with propofo

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📋 Eligibility rules (as published)
Inclusion Criteria: * Planned transurethral operation in the department of urology. * Preoperative IIEF-5 Score ≥12 * Planned surgery time ≥15min Exclusion Criteria: * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * Inability to provide informed consent. * Contraindications to Propofol or Sevoflurane, e.g. known hypersensitivity or allergy. * Known or suspected non-compliance, drug or alcohol abuse. * Participation in another study with an investigational drug within the 30 days preceding and during the present study. * Previous enrolment into the current study. * Enrolment of the investigator, his/her family members, employees and other dependent persons.
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What it tests

  • General Anesthesia: Propofol
  • General Anesthesia: Sevoflurane
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Where

1 site
University Hospital Zurich
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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