Stepwise Heat-Denaturated Protein Introduction for Tolerance Induction in Food Allergy

Inclusion Criteria: * Children (1-18y) had or have a clinical diagnosis of IgE mediated cow's milk allergy based on positive history as well as skin prick testing and/or specific IgE detection by CAPtest in an allergy clinic. * Children are at least 12 months old before introduction of heated cow's milk is considered. * Children did not suffer from grade 4 anaphylaxis due to cow's milk-ingestion at presentation. * Children have specific IgE levels to Bos d 8 below 1.2 kU/mL and/or children passed 20' cooked cow's milk provocation test executed on clinical judgement. Exclusion Criteria: * Children had grade 4 anaphylaxis due to cow's milk ingestion. * Children are younger than 12 months old at the moment of passing 20' cooked cow's milk OFC. * Parents are not able or not willing to adhere to a specific cow's milk protein-containing diet on a regular basis at home. * Multiple food allergy, not compatible with any of the choices in the Flemish Milk Ladder. * Parents and/or children are not willing to give IC/assent.