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The PRO-FUTURE Project

Recruitingn/aAges 1 Day - 5 YearsAllUniversity of Campania Luigi Vanvitelli
NCT06382233 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are: * Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies? * Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?

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📋 Eligibility rules (as published)
Inclusion Criteria: * unilateral UPJO * 0-5years of age Exclusion Criteria: * bilateral UPJO * previous surgical intervention on the urinary tract * bladder or lower urinary tract symptoms or malformations * nephro- or urolithiasis, vesicoureteral reflux * urinary tract infections.
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What it tests

  • Identification of Diagnostic Biomarkers
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Where

5 sites
Univeristà degli Studi della Campania Luigi Vanvitelli
Naples, Italy
Department of Clinical Sciences and Community Health, University of Milano
Milan, Italy
Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico
Milan, Italy
Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia
Modena, Italy
AORN Santobono-Pausilipon
Naples, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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