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Artificial Intelligence in ANOCA

RecruitingNAAges 18 Years - anyAllUMC Utrecht
NCT06387693 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Angina pectoris is diagnosed in \>180.000 people in the Netherlands each year. Diagnosis in angina pectoris focuses on epicardial coronary stenosis, the identification of which may lead to guideline-directed medical therapy or revascularization. However, no such stenosis is identified in 40-70% of patients. This condition, angina with no obstructed coronary artery (ANOCA), is more prevalent in women and is related to poor quality of life, high medical expenses, and a higher incidence of adverse events. The origin of ANOCA can be evaluated during invasive coronary angiography by coronary function testing (CFT) to identify coronary vasomotor disorders. This relates to vasospasm of the coronary artery and microcirculation, or to impaired microvascular vasodilation. For the diagnosis of vasospasm, CFT needs to result in electrocardiographic signs of myocardial ischemia as part of the diagno

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Clinical indication for comprehensive coronary function testing because of persisting chest discomfort at least 2 times per week despite current medical therapy. 2. Absence of obstructive coronary artery disease with an indication for revascularization, documented by means of recent coronary computed tomography angiography (CCTA) or invasive coronary angiography (with invasive coronary pressure measurements if clinically indicated). 3. Patient is willing and able to provide written informed consent. Exclusion Criteria: 1. Absence of chest discomfort after initiation of medical therapy. 2. Language barrier preventing sufficient understanding and communication in Dutch.
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What it tests

  • Holter monitoring, intracoronary ECG
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Where

1 site
UMC Utrecht
Utrecht, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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