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The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents

Recruitingn/aAges 11 Years - 17 YearsAllUniversity Ghent
NCT06391671 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity. The investigators will assess the following hypotheses: * Weight condition is reflected by the fecal metabolome (WP1) * Emotional stress is implicated in weight condition (WP1) * Functionality of the gut microbiome is related to the diet-stress-obesity axis (WP2) * Dietary pattern impacts the fecal metabolome and gut microbiome (WP2) * Personalized dietary intervention outperforms generalized dietary approaches (WP3) Participants will: * Produce a saliva, stool and hair sample * Fill in questionnaires regarding mental health, medical health and demographic information * Fill in a food frequency questionnaire and a 24-hrecalls * Be measured (height, weight, fat% and waist circumference) The

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 11-17 years Exclusion Criteria: * Obesity/overweight * Type 1 diabetes * Medical conditions including pancreatic failure * Developmental and hormonal disorders. E.g. thyroid problems, adrenal problems, Kallmann's syndrome, Klinefelter's syndrome, Prader-Willi syndrome (PWS), Congenital hypogonadotropic hypogonadism (CHH), ... * Pregnancy * In treatment with systemic concentrations of corticosteroids (cortisone). Eg cortisone/betamethasone/Dexamethasone/Fludrocortisone/Hydrocortisone in pill form or administration by injections.
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What it tests

  • Collection of anthropometric data, biological samples (stool, saliva and hair), questionnaires (demographic data, psychological data, medical data)
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Where

7 sites
AZ Jan Palfijn Gent, Oost-Vlaanderen, Belgium, 9000
Ghent, Belgium
Ghent University Hospital
Ghent, Belgium
Clairs Vallons
Ottignies-Louvain-la-Neuve, Belgium
Zeepreventorium
De Haan, Belgium
AZ Delta
Roeselare, Belgium
UZ Antwerpen
Antwerp, Belgium
ZNA Middelheim
Antwerp, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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