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PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT06394180 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A large, worldwide study called PREVENT is looking at a complication that can happen during a stroke treatment called thrombectomy. This complication is a perforation of a blood vessel. The investigators aim to: 1. Find what factors make this perforation more likely. 2. Understand why the perforation happens by looking closely at images taken during the procedure. 3. Create a simple way to classify these perforations to help doctors decide how to treat them right away. 4. Improve the emergent treatment of vessel perforation to stop the bleeding rapidly. 5. Provide data to guide decision whether thrombectomy should be continued or aborted after the event of vessel perforation. 6. Develop a safer way to perform thrombectomy. Investigators will compare the results collected for patients where perforation happened with those where perforation did not happen.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years at time of thrombectomy * Acute ischemic stroke with occlusion of one or several intracranial arteries and subsequent thrombectomy. * Target cohort: Occurrence of intracranial perforation during thrombectomy with evidence of contrast extravasation in at least one diagnostic angiography series. * Comparison cohort: No perforation during thrombectomy. Every patient in the comparison group is matched to one patient in the target population. Matching will be carried out with respect to age, gender, participating center and location of the vascular occlusion. Exclusion Criteria: * Presence of a documented rejection * Presence of both ischemic stroke and intracranial hemorrhage on pre-interventional imaging. * Patients with intracranial dissection without active contrast extravasation. * Patients with rupture of a pre-existing intracranial aneurysm during thrombectomy. * Patients with contrast medium extravasation into a venous space instead of free contrast medium extravasation, e.g. the cavernous sinus with consecutive development of a carotid-cavernous fistula.
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What it tests

  • Not listed
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Where

1 site
University Hospital Basel
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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