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The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate

RecruitingPhase 4Ages any - anyAllSemmelweis University
NCT06401083 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to answer whether the use of a single loading dose (20 mg/kg) of caffeine citrate one hour before extubation has an impact on the success rate of extubation among preterm neonates. In addition, the investigators would like to assess the frequency of apneas and side effects of the intervention, as well as the development of NEC, BPD, IVH, PVL, and long-term neurodevelopmental outcomes in the investigated populations. According to institutional protocol, preterm infants born before the 32nd week of gestation receive a standard dose of caffeine citrate therapy. This covers a maintenance dose of 5-10 mg/kg of caffeine citrate administered intravenously once or twice daily after a loading dose of 20 mg/kg on the first day of life. In this trial, preterm infants born before the 32nd gestational week and who had been mechanically ventilated for at least 48 ho

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📋 Eligibility rules (as published)
Inclusion Criteria: * Premature infant born before 32nd week of gestation is completed; * Had been mechanically ventilated for at least 48 hours; * Before the first planned extubation. Exclusion Criteria: * Lack of informed consent, refusal to participate in the study; * Major congenital anomaly; * Had not received surfactant treatment; * Hydrops foetalis; * Persistent tachycardia before extubation, fetal/neonatal arrhythmia; * Asphyxia.
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What it tests

  • Caffeine citrate
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Where

2 sites
Pediatric Center, Semmelweis University
Budapest, Hungary
Department of Obstetrics and Gynecology, Semmelweis University
Budapest, Hungary
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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