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Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)

RecruitingPhase 2Ages 18 Years - anyAllUniversité du Québec à Trois-Rivières
NCT06401317 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Thumb osteoarthritis or trapeziometacarpal osteoarthritis (TMO) is a common and painful form of hand arthritis that limits thumb mobility and hand function, affecting patients' quality of life. Although corticosteroids injections are a typical treatment, their effectiveness has been challenged, and side effects have been reported. Recent studies suggest that saline injections, usually considered inactive, might be a viable treatment option. The primary goal of this study is to compare the effectiveness of saline injections versus corticosteroids injections in reducing TMO-related pain and improving hand function. In this study, 40 people with TMO will be randomly assigned to receive either a corticosteroids or a saline injection, without them or the doctors performing the injection knowing which one was administered (double blind). If saline injections prove more effective, they could pr

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📋 Eligibility rules (as published)
Inclusion Criteria: * aged ≥18 years; * diagnosis of TMO was confirmed by X-ray interpreted by a radiologist; * suffering from pain at the base of the thumb; * the attending physician deems that an intra-articular corticosteroid injection would be beneficial, rather than opting for other types of intervention such as surgery * can read, understand and answer in either French or English. Exclusion Criteria: * having received one or more corticosteroid injections in the last 3 months or surgery on the affected thumb; * suffering from painful thumb caused by a trauma (e.g., fracture, sprain), rheumatoid arthritis, or De Quervain's tendonitis; and * being pregnant or breastfeeding; and * known allergies to any components of the solutions (triamcinolone acetonide, benzyl alcohol, carboxymethylcellulose sodium, hydrochloric acid, polysorbate, sodium chloride, or sodium hydroxide) or to iodinated contrast media.
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What it tests

  • Saline Solution (NaCl 0,9%)
  • Triamcinolone Acetonide
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Where

2 sites
Centre Hospitalier de l'Université de Montréal - Physiatry
Montreal, Canada
Centre Hospitalier de l'Université de Montréal - Chirurgie plastique
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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