Sacituzumab Govitecan and Bevacizumab for NSCLC Brain Metastases

Inclusion Criteria: * In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Signed informed consent must be obtained prior to participation in the study. 2. Participant is an adult ≥ 18 years of age at the time of informed consent. 3. ECOG performance status ≤1. 4. Estimated life expectancy of 12 weeks or more. 5. Pathology proven metastatic non-squamous NSCLC 6. For those without an actionable oncogenic driver: progression on immunotherapy and/or platinum-doublet chemotherapy (concurrent or sequential, in any order). If contra-indication for immunotherapy: progression on platinum-doublet chemotherapy. 7. For those with an actionable oncogenic driver: progression on targeted therapy and platinum-doublet chemotherapy. For the latter group, previous ICI is allowed but not mandatory. 8. BM not in eloquent area (all patients have at least to be discussed with a neurologist, and preferably they are discussed in the local neuro-oncology MDT). 9. Maximum BM size 2 cm in longest diameter (for each BM). 10. At least one untreated brain metastasis ≥ 5mm: 1. Patients with largest measurable intracranial lesion ≥5 mm but \<10 mm may be allowed to enroll upon agreement with the principal investigator (for patients with target lesions of ≥ 5mm but \<10 mm, 1.5 mm slice thickness brain MRI is required). 2. Prior local treatment is permissible provided unequivocal progression in the lesion has since occurred (discussed in neuro-oncology MDT) or if new lesions have occurred. 3. For at least 7 days prior to first dose of SG and bevacizumab in this study: Patient must be asymptomatic from CNS metastases and on a stable dose of corticosteroids, with a maximum of 4 mg dexamethasone/day. Anti-epileptic dose should also be stable for 7 days. 11. Participant must have recovered from all toxicities related to prior treatments to grade ≤ 1 (CTCAE v 5.0). Exception to this criterion are alopecia and neuropathy of any grades. 12. Adequate organ function including the following laboratory values at the screening visit: * Absolute neutrophil count (ANC) ≥ 1.5 x 109/L (without growth factor support), * Platelets ≥ 100 x 109/L (without growth factor support), * Hemoglobin (Hb) ≥ 6 mmol/l (= 9 g/dl) (7 days without transfusions or growth factor support), * Aspartate transaminase (AST) ≤ 2.5 x ULN, or ≤ 5 × ULN if known liver metastases * Alanine transaminase (ALT) ≤ 2.5 x ULN, or ≤ 5 × ULN if known liver metastases * Serum albumin \> 3 g/dL * Total bilirubin ≤ 1.5 ULN, * Creatinine clearance ≥ 30 mL/min by calculation using Cockcroft-Gault formula or based on 24-hour urine sample assessment. 13. Participant is capable of following instructions regarding study treatment administration, and must be able to communicate with the Investigator and comply with the requirements of the study procedures. 14. Negative serum or urine pregnancy test within 7 days prior to study treatment in women with childbearing potential. Patient must be willing to use effective methods of contraception. Female patients must be postmenopausal, surgically sterile, or they must agree to use a physical barrier method of contraception in addition to either an intrauterine device or hormonal contraception until at least 4 months after termination of study drug. Exclusion Criteria: * A potential subject who meets any of the following criteria will be excluded from participation in this study: 1. Leptomeningeal metastasis (based on MRI or CSF cytology, if strong suspicion despite negative MRI, CSF analysis should be done). 2. Previous treatment with TROP2 inhibitor or angiogenesis inhibitor. 3. Known hypersensitivity to the study drugs, its metabolites, or formulation excipient. 4. Positive serum pregnancy test or women who are breastfeeding. 5. Contra-indication for MRI. 6. History of allogeneic bone marrow or solid organ transplant. 7. Have had a prior anticancer biologic agent (ADC, ICI) within 4 weeks prior to enrolment or have had prior chemotherapy, targeted small molecule therapy, or radiation therapy within 2 weeks prior to enrolment and have not recovered (ie, ≥ Grade 2 is considered not recovered) from AEs at the time of study entry. a. Note: Patients participating in observational studies are eligible. 8. Have not recovered (ie, ≥ Grade 2 is considered not recovered) from AEs due to a previously administered agent. 1. Note: patients with any grade vitiligo or alopecia are an exception to this criterion and will qualify for the study. 2. Note: if patients received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting therapy. 9. Have an active second malignancy. Note: patients with a history of malignancy that has been treated completely, with no evidence of active cancer for 3 years prior to enrollment, or patients with surgically cured tumours with low risk of recurrence (eg, nonmelanoma skin cancer, histologically confirmed complete excision of carcinoma in situ, or similar) are allowed to enroll. 10. Met any of the following criteria for cardiac disease: 1. Myocardial infarction or unstable angina pectoris within 6 months of enrollment. 2. History of serious ventricular arrhythmia (ie, ventricular tachycardia or ventricular fibrillation), high-grade atrioventricular block, or other cardiac arrhythmias requiring antiarrhythmic medications (except for atrial fibrillation that is well controlled with antiarrhythmic medication); history of QT interval prolongation. 3. New York Heart Association (NYHA) class III or greater congestive heart failure or left ventricular ejection fraction of \< 40%. 11. Have active chronic inflammatory bowel disease (ulcerative colitis, Crohn's disease) or GI perforation within 6 months of enrolment. 12. Have active serious infec