Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients

Inclusion Criteria: * Patients who had a first-time ischemic stroke due to MCA atherosclerosis stenosis more than 50% and admitted to our hospital within 7 days after onset. * Patients are more than 45 years old. * Patients had HR-MRI and have done the full stroke workup (including carotid duplex scanning, fasting lipid profile, Holter ECG 24 hours, cardiac ultrasound,...) Exclusion Criteria: * Patients also have stenosis of the carotid artery (more than 50%) or occulsion on the same side of ischemic stroke * Patients also have an ischemic stroke in territories other than MCA territory. * Patients had any characteristics that suggested other causes for their stenosis, including moyamoya, dissection, and inflammation on their MRI and HR-MRI. * Patients with evidence suggestive of cardioembolism (Atrial fibrillation, decreased EF \<50%, recent heart attack in 3 weeks, rheumatic valvular heart disease, dilated cardiopathy, sick sinus syndrome, infective endocarditis). * Any signs suggestive other causes (non atherosclerosis etiology), including autoimmune disease or increased coagulation state. * Patients with severe concomitant disease could affect the 6-month follow-up of the patients.