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Opioid-free Anaesthesia in Breast Cancer Surgery

RecruitingNAAges 18 Years - 99 YearsFemaleUniversity of Ioannina
NCT06404983 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Various analgesic modalities are adopted for perioperative analgesia in breast cancer surgeries. Opioid-free and opioid-sparing techniques are gaining popularity due to the lack of opioid-dependent undesirable effects, including respiratory depression, urinary retention, nausea and vomiting, constipation, itching, opioid-induced hyperalgesia, tolerance, addiction, and immune system disorders. The goal of this prospective randomized clinical trial is to investigate the impact of opioid-free anaesthesia (OFA) versus conventional general anaesthesia (CGA) on postoperative analgesic requirements after breast cancer surgery (lumpectomy/mastectomy, with or without axillary lymph node excision). Secondary objectives include comparative perioperative evaluation of cognitive function and postoperative adverse events during the first 48 hours atfter surgery. Comparative evaluation o

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📋 Eligibility rules (as published)
Inclusion Criteria: * adult patients * breast cancer surgery (mastectomy, lumpectomy, with or without lymph node excision) under general anaesthesia Exclusion Criteria: * under 18 years * patient refusal * opioid use (systemic or not) for any reason (e.g., chronic malignant pain) * language barrier (difficulty in communicating in Greek language) * allergy to the administered agents * severe arrhythmia or other serious cardiac disease * severe liver and kidney failure * dementia, psychiatric diseases, and/or preoperative cognitive impairment
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What it tests

  • Opioid Free Anaesthesia (OFA)
  • Conventional General Anaesthesia (CGA)
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Where

1 site
University Hospital of Ioannina
Ioannina, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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