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Micro-movements in Patients With Prolonged Disorders of Consciousness

Recruitingn/aAges 18 Years - 80 YearsAllFirst Affiliated Hospital of Zhejiang University
NCT06406413 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness. The main questions it aims to answer are: Use the neuropsychological paradigm model to monitor micro-movements, assess the patient's remaining level of consciousness and accurately classify it; screen out patients with cognitive-motor dissociation to improve the prognosis of cognitive function; explore the remaining brain function of patients with chronic disorders of consciousness and promote relevant study of neural mechanisms. Participants will be subjected to consciousness assessment by CRS-r scale, and their micro-movement changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS; 2. Aged between 18 and 80 years; 3. Stable vital signs; 4. Voluntary participation of family members with signed informed consent; 5. Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs. Exclusion Criteria: 1. Locked-in syndrome; 2. Contraindications for EEG examination; 3. Contraindications for MRI scanning, such as the presence of internal metallic implants; 4. Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.
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What it tests

  • micro-movement; electroencephalogram; MRI
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Where

1 site
First Affiliated Hospital,Zhejiang University
Hanzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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