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Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy

RecruitingNAAges 18 Years - 80 YearsAllBeijing Tiantan Hospital
NCT06406842 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Carotid endarterectomy (CEA) is used to treat symptomatic extracranial internal carotid artery stenosis. The occult stroke of CEA patients evaluated by magnetic resonance imaging 3 days after operation was as high as 17%. Cerebral blood flow autoregulation (CA) is the ability of the brain to maintain the relative stability of cerebral blood flow, and cerebral oxygen index (COx) can be used to reflect CA. A negative value of cerebral oxygen index or a value near zero indicates that CA is complete, and cerebral oxygen index close to 1 indicates that CA has lost its ability. In theory, real-time monitoring of CA function by cerebral oxygen index and individualized management strategy with this goal can potentially reduce perioperative ischemic brain injury. The purpose of this study is to explore the influence of the management strategy of monitoring CA function based on regional cerebral o

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients scheduled for elective carotid endarterectomy * ASA Ⅱ or Ⅲ * aged 18-80 years old Exclusion Criteria: * preoperative moderate and severe cognitive impairment * preoperative psychotropic medication history within one year * history of neurosurgery * have speech or language impairments
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What it tests

  • Cerebral oxygenation index guided hemodynamics management
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Where

2 sites
Xuanwu Hospital, Capital Medical University
Beijing, China
Beijing Tian Tan Hospital, Capital Medical University
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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