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Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations

Recruitingn/aAges 6 Years - anyAllUniversity Hospital, Toulouse
NCT06408701 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Ocular morphogenesis is a complex process starting as early as the 4th week of embryonic life, involving interactions between varioustissues of different origin and conserved genes. Anomalies in ocular development , often of genetic origin, pose diagnostic and therapeutic challenges. Animal models are limited, so human-induced pluripotent stem cell (hiPSC)-derived optic vesicle containing brain organoids (OVBOs) offer a promising alternative. These pathological OVBOs, created from patients' cells with ocular malformations, allow for the study of underlying molecular mechanisms and testing of therapies.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Affiliated with a social security scheme. * Patients with ocular malformations. * Signed informed consent obtained from the patient and/or their legal representatives. Exclusion Criteria: * Inability to understand the nature and objectives of the study and/or difficulties in communicating with the investigator. * Deprivation of liberty by judicial or administrative decision. * Any other pathological or psychological condition deemed incompatible by the investigator for the proper conduct of the study.
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What it tests

  • Blood sampling
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Where

2 sites
CHU de Clermont-Ferrand - Hôpital d'Estaing
Clermont-Ferrand, France
Purpan University Hospital
Toulouse, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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