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FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage

RecruitingPhase 2Ages 18 Years - anyAllThe George Institute
NCT06409364 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage. The study aim is to determine if early administration of enteral fludrocortisone in aneurysmal subarachnoid haemorrhage reduce death and dependency at six months.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 18 years or older 2. Diagnosed with subarachnoid haemorrhage from an aneurysm confirmed on computed tomography angiography (CTA) or digital subtraction angiography (DSA) of the intra-cranial arteries 3. Aneurysm has been secured 4. Hospital admission for aSAH within 96 hours 5. Currently being treated in a critical care environment Exclusion Criteria: 1. Unable to receive enteral medications 2. Pre-existing glucocorticoid or mineralocorticoid treatment 3. Previous allergic reaction to fludrocortisone 4. History of cardiac, hepatic, or renal failure 5. Hypernatremia or hyponatremia (Na\>145mmol/L or Na\<125mmol/L) on the most recent blood sample at the time of screening. 6. Death deemed imminent or inevitable 7. Pregnancy (confirmed or suspected) 8. Previous inclusion in the FLASH trial
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What it tests

  • Fludrocortisone
  • Placebo
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Where

16 sites
John Hunter Hospital
New Lambton Heights, Australia
Nepean Hospital
Penrith, Australia
Prince of Wales Hospital
Randwick, Australia
Royal North Shore Hospital
St Leonards, Australia
Westmead Hospital
Westmead, Australia
Wollongong Hospital
Wollongong, Australia
Royal Brisbane Women's Hospital
Brisbane, Australia
Gold Coast University Hospital
Gold Coast, Australia

…and 8 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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