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Impact of an Early Warning System on the Prognosis of Patients With Hematological Malignancies Receiving Intensive Chemotherapy With or Without Hematopoietic Cell Transplantation.

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Angers
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In plain words

What the trial is, and whether it could suit you

Patients with hematologic malignancies requiring intensive chemotherapy are at risk for life-threatening complications. Organ failure may appear rapidly and delay in initiating life-sustaining interventions may result in increased mortality. This encourages great alertness although not all patients require close monitoring. It is therefore critical to identify which patients are the most at risk for clinical deterioration to consider increased surveillance in these patients. The benefit of early intensive care unit (ICU) admission, as soon as the first signs of organ dysfunction appear, must also be clarified. Such an intervention could increase survival of patients by close monitoring and early initiation of organ-specific interventions but could also be responsible for anxiety and increased use of ICU resources. Many teams have analyzed the impact of early warning systems (EWS) includ

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patient * Hospitalization in a protected unit of a hematology department for induction therapy of acute myeloid leukemia or acute lymphoblastic leukemia induction, intensive chemotherapy with autologous hematopoietic cell transplantation, allogeneic hematopoietic cell transplantation * Expected length of stay in the hematology department of at least 7 days * Patient with social security * Signed informed consent form Exclusion Criteria: * Decision of care limitation with decision not to transfer to ICU or not initiate organ support * Pregnant, parturient or breastfeeding woman * Person deprived of liberty by judicial or administrative decision * Person under forced psychiatric care * Person under legal protection * Person unable to express consent * Hospitalization for Chimeric Antigenic Receptor (CAR) T-cell therapy
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What it tests

  • Real-time calculation of the NEWS with ICU admission if NEWS ≥ 7.
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Where

10 sites
Centre Hospitalier Amiens-Picardie
Amiens, France
Centre Hospitalier Universitaire d'Angers
Angers, France
Centre Hospitalier Universitaire Besancon
Besançon, France
Centre Hospitalier Universitaire Brest
Brest, France
Centre Hospitalier universitaire Nancy
Nancy, France
Centre Hospitalier Universitaire Nantes
Nantes, France
Centre Hospitalier Universitaire poitiers
Poitiers, France
centre Hospitalier Universitaire Saint etienne
Saint-Etienne, France

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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