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MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology

RecruitingNAAges 21 Years - anyAllUniversity of Nebraska
NCT06409949 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In our research, we are delving into whether taking MitoQ for six months can improve the symptoms and function of people diagnosed with peripheral artery disease, especially those who suffer from leg pain while walking, known as intermittent claudication. We will be checking if MitoQ helps people with claudication walk better, be more active every day, feel better about their lives, and if it enhances the health of their leg muscles.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. a positive history of chronic claudication 2. exercise-limiting claudication established by history and direct observation during a screening walking test administered by the evaluating vascular surgeon 3. documented lower extremity arterial occlusive disease based on ankle/brachial index measurements and/or arterial imaging 4. stable blood pressure, lipid and diabetes regimens and risk factor control for 6 weeks. Exclusion Criteria: 1. rest pain or tissue loss due to PAD (Fontaine stage III and IV) 2. acute lower extremity ischemic event 3. walking capacity significantly and primarily limited by conditions other than claudication including leg (joint/musculoskeletal, neurologic) and systemic (heart, lung disease) pathology.
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What it tests

  • Walking assessment
  • QOL Survey
  • Ankle pressure at rest and after stress
  • Muscle Oxygen
  • Serum MitoQ Level
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Where

1 site
VA Medical Center
Omaha, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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