🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Retinal Vessel Leakage in Cerebral Small Vessel Disease

Recruitingn/aAges 18 Years - anyAllUniversity of Edinburgh
NCT06416371 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: * Does retinal vessel leakage occur in cerebral small vessel disease? * If it does, is the severity of retinal vessel leakage similar to the severity of cerebral small vessel disease generally? Participants will be tested using fluorescein angiography. This involves an intravenous injection of fluorescent dye, and is a very sensitive way to find leakage from retinal blood vessels. Participants will have already had brain scans and other examinations and tests to measure the severity of their cerebral small vessel disease. Our new retinal images will complement the information from these previous tests.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Membership in the Mild Stroke Study 3 cohort * Contrast enhanced MRI within 12 months * Clear optical media in both eyes, as assessed by study investigator * Best corrected visual acuity (near vision) ≥N36 Exclusion Criteria: * Any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension) * Previous treatment for retinal leakage (retinal laser, intravitreal anti-VEGF) * Recent eye surgery * Shallow anterior chambers as assessed by torch test * Pregnancy, renal failure * Severe dementia * Known allergy to fluorescein * History of allergy such as food or drug induced urticaria or history of bronchial asthma * Any other severe or acute medical or psychiatric conditions * Inability to give informed consent
💊

What it tests

  • Fundus fluorescein angiography, with ultrawide field retinal imaging
📍

Where

1 site
NHS Lothian
Edinburgh, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy