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Autopsy and Photon Counting Computed Tomography to Evaluate Thromboses Related to Central Venous Catheters

Recruitingn/aAges 18 Years - anyAllThomas Kander
NCT06417541 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical CVK-related thrombosis (Rockholt et al.). To shed light on this problem, the current studies were designed. In sub-study 1, deceased patients with CVC who are referred for clinical autopsy are included. Before the autopsy, the deceased will be examined with a photon-counting computed tomography (CT) scan and the results will be compared. In sub-study 2, living patients with CVC who are referred for various CT scans without contrast, are included. After informed consent, the patient will be examined with the photon-counting CT, whose reliability has been validated in Part 1 and the incidence of subclinical CVC-related thrombosis will be reported.

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📋 Eligibility rules (as published)
Substudy 1 Inclusion Criteria: * Diseased patients with an indwelling central venous catheter and a clinical indication for autopsy * Informed and signed consent from next of kind Exclusion Criteria: * None Substudy 2 Inclusion Criteria * Living patients with an indwelling central venous catheter who are referred to a CT scan without iv contrast * Informed and signed consent from the patient Exclusion Criteria \- GFR \<15 mL/min/1.73 m2
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What it tests

  • Diseased patients with an indwelling central venous catheter who is referred to autopsy
  • Living patients with an indwelling central venous catheter referred to a CT scan without iv contrast
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Where

1 site
Intensive and Perioperative Care. Skåne University Hospital. Lund
Lund, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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