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Effects of Cerebellar tACS-iTBS in Ataxia

RecruitingNAAges 8 Years - 80 YearsAllI.R.C.C.S. Fondazione Santa Lucia
NCT06420271 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Ataxia refers to a group of neurological disorders characterized by impaired coordination and balance due to dysfunction in the cerebellum or its connections. Traditional therapeutic approaches for ataxia have shown limited efficacy, prompting researchers to explore alternative interventions. Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and intermittent theta burst stimulation (iTBS), have emerged as potential therapeutic options. The aim of this study is to investigate the combined effect of tACS-iTBS on balance functions in ataxia disorders.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Confirmed diagnosis of ataxia based on clinical assessment and/or neuroimaging findings. 2. Stable medication regimen for at least four weeks prior to the study. 3. Sufficient cognitive ability to understand and comply with study instructions. Exclusion Criteria: 1. History of seizures. 2. Severe general impairment or concomitant diseases. 3. Intracranial metal implants. 4. Cardiac pacemaker. 5. Pregnancy status.
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What it tests

  • Real (real iTBS/tACS + exergaming)
  • Sham (sham iTBS/tACS + exergaming)
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Where

1 site
IRCCS Santa Lucia Foundation
Rome, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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